A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women

20051,949 citationsJournal Article

Authors

Paul M. Ridker · Harvard University

Nancy R. Cook · Brigham and Women's Hospital

I‐Min Lee

David Gordon · Brigham and Women's Hospital

J. Michael Gaziano · Brigham and Women's Hospital

JoAnn E. Manson · Harvard University

Charles H. Hennekens · Florida Atlantic University

Abstract

In this large, primary-prevention trial among women, aspirin lowered the risk of stroke without affecting the risk of myocardial infarction or death from cardiovascular causes, leading to a nonsignificant finding with respect to the primary end point.

Topics & Keywords

Antiplatelet Therapy and Cardiovascular Diseases Inflammatory mediators and NSAID effects Lipoproteins and Cardiovascular Health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 352, Issue 13, pp. 1293-1304

DOI: 10.1056/nejmoa050613

Field-Weighted Citation Impact: 119.72