IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF- and IL-17

2008352 citationsJournal Article

Authors

Misato Hashizume · Chugai Pharma (United States)

Abstract

IL-6/sIL-6R directly induced RANKL expression in RA-FLS and it is essential for RANKL induction by TNF-alpha and IL-17. Moreover, RANKL induction by IL-6/sIL-6R is mediated by the janus kinase/STAT signalling pathway.

Topics & Keywords

NF-κB Signaling Pathways Cytokine Signaling Pathways and Interactions Bone Metabolism and Diseases

Publication Details

Published in: Lara D. Veeken

Volume 47, Issue 11, pp. 1635-1640

DOI: 10.1093/rheumatology/ken363

Field-Weighted Citation Impact: 5.27

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IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF- and IL-17

Authors

Abstract

Topics & Keywords

Publication Details