MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals

2008208 citationsJournal Articlegold Open Access

Authors

Laurent Houzet · National Institute of Allergy and Infectious Diseases

Man Lung Yeung · National Institutes of Health

Valéry de Lame · Saint Michael's Medical Center

Deepashree N Desai · Saint Michael's Medical Center

Stephen M. Smith · Saint Michael's Medical Center

Kuan‐Teh Jeang · National Institutes of Health

Abstract

MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.

Topics & Keywords

HIV Research and Treatment MicroRNA in disease regulation RNA Interference and Gene Delivery

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Retrovirology

Volume 5, Issue 1, pp. 118-118

DOI: 10.1186/1742-4690-5-118

Field-Weighted Citation Impact: 3.96