Intestinal handling-induced mast cell activation and inflammation in human postoperative ileus

2007154 citationsJournal Articlebronze Open Access

Authors

FO The · Academic Medical Center

Roel J. Bennink · Academic Medical Center

W.M. Ankum · Academic Medical Center

M. R. Buist · Academic Medical Center

O.R. Busch · Academic Medical Center

D.J. Gouma · Academic Medical Center

S. van der Heide ·

Abstract

This study demonstrates that intestinal handling triggers mast cell activation and inflammation associated with prolonged postoperative ileus. These results may partly explain the faster recovery after minimal invasive surgery and encourage future clinical trials targeting mast cells to shorten postoperative ileus.

Topics & Keywords

Enhanced Recovery After Surgery Cancer, Stress, Anesthesia, and Immune Response Endometriosis Research and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 57, Issue 1, pp. 33-40

DOI: 10.1136/gut.2007.120238

Field-Weighted Citation Impact: 7.29