Statin-Sensitive Dysregulated AT1 Receptor Function and Density in Hypercholesterolemic Men

1999393 citationsJournal Article

Authors

Georg Nickenig · Centrum für Integrierte Onkologie

Anselm T. Bäumer · Centrum für Integrierte Onkologie

Yavuz Temur · Centrum für Integrierte Onkologie

Daniela Kebben · Centrum für Integrierte Onkologie

F. Jockenhövel · Centrum für Integrierte Onkologie

Michael Böhm · Centrum für Integrierte Onkologie

Abstract

Hypercholesterolemia induces AT1 receptor overexpression and enhances biological effects of angiotensin II in men. These findings provide novel insights into the pathogenesis of hypertension and atherosclerosis and may initiate rational and new therapeutic concepts.

Topics & Keywords

Lipoproteins and Cardiovascular Health Hormonal Regulation and Hypertension Receptor Mechanisms and Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 100, Issue 21, pp. 2131-2134

DOI: 10.1161/01.cir.100.21.2131

Field-Weighted Citation Impact: 18.19