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Differences between BG and DG and IFG respectively were significant (P Ͻ0.0001).Correlation between BG and DG (r 2 ϭ 0.79) was not significantly improved with the ionic reference technique (r 2 ϭ 0.86) (P ϭ 0.37).Bland-Altman analysis comparing IFG to BG is shown in Fig. 1.Microdialysis of adipose tissue adequately reflects BG in the setting of diabetes (4 ) and healthy volunteers.In this study in critically ill children, the correlation between BG and IFG was moderate.Bland-Altman analysis, however, indicated that the microdialysis technique is unsuitable to replace frequent blood sampling to safely monitor TGC in this patient group.The difference using IFG for BG was unacceptable in the clinically relevant glycemic ranges and this difference could be both negative or positive (Fig. 1); thus hyper-and/or hypoglycemia may be undiagnosed when only IFG is measured and therapeutic adjustments are based on this value.These results confirm those of previous studies (5 ) concluding that the correlation between BG and IFG of adult intensive care unit (ICU) patients is not as good as in healthy or diabetic individuals.It remains speculative whether this is a result of the particular patient population with disturbed microvasculature and treatment with vasoactive drugs.We used a flow rate of 1 L/min to avoid the delay in detection of changes in IFG that occurs at lower flow rates and to avoid an insufficient hourly sample volume.Higher flow rates, however, can lead to local depletion of metabolites and dilution of the dialysate.Lower flow rates facilitate the capture of true interstitial glucose concentrations during glucose fluctuations.No drugs known to interfere with the used methodology of glucose measurements were administered.Before microdialysis of the subcutaneous adipose tissue can be safely implemented for TGC in pediatric intensive care units, more studies are necessary to identify interfering factors and to optimize the performance of the current technology.