Liquid-Liquid Phase Separation in Biology

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Authors

Anthony A. Hyman · Max Planck Institute of Molecular Cell Biology and Genetics

Christoph A. Weber · Max Planck Institute for the Physics of Complex Systems

Frank Jülicher · Max Planck Institute for the Physics of Complex Systems

Abstract

Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary to understand the consequences of liquid-like states for biological functions.

Topics & Keywords

RNA Research and Splicing Cellular Mechanics and Interactions Nuclear Structure and Function

Publication Details

Published in: Annual Review of Cell and Developmental Biology

Volume 30, Issue 1, pp. 39-58

DOI: 10.1146/annurev-cellbio-100913-013325

Field-Weighted Citation Impact: 27.81

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Liquid-Liquid Phase Separation in Biology

Authors

Abstract

Topics & Keywords

Publication Details