Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics

2003511 citationsJournal Article

Authors

Yohei Nishizato · Tottori University Hospital

Abstract

Certain commonly occurring single-nucleotide polymorphisms in OATP-C, such as T521C (Val174Ala), are likely to be associated with altered pharmacokinetics of pravastatin. Large clinical studies are needed to confirm these observations.

Topics & Keywords

Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies Pharmacogenetics and Drug Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Pharmacology & Therapeutics

Volume 73, Issue 6, pp. 554-565

DOI: 10.1016/s0009-9236(03)00060-2

Field-Weighted Citation Impact: 18.42