Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy

2003134 citationsJournal Articlebronze Open Access

Authors

Miia Savander · University of Helsinki

A Ropponen · Helsinki University Hospital

K Avela · University of Helsinki

N Weerasekera · Hammersmith Hospital

B Cormand · Universitat de Barcelona

M-L Hirvioja · Kanta-Hämeen Keskussairaala

S Riikonen · Helsinki University Hospital

O Ylikorkala

Abstract

These results support the hypothesis that the aetiology of ICP is heterogeneous and that ICP is due to a genetic predisposition in a proportion of patients. The results of molecular genetic analysis further suggest that the previously identified three cholestasis genes are not likely to be implicated in these Finnish ICP families with dominant inheritance.

Topics & Keywords

Drug Transport and Resistance Mechanisms Pediatric Hepatobiliary Diseases and Treatments Pharmacological Effects and Toxicity Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 52, Issue 7, pp. 1025-1029

DOI: 10.1136/gut.52.7.1025

Field-Weighted Citation Impact: 4.96