Step-up Therapy for Children with Uncontrolled Asthma Receiving Inhaled Corticosteroids

2010441 citationsJournal Articlebronze Open Access

Authors

Robert F. Lemanske · Wisconsin Division of Public Health

David T. Mauger · University of California, San Diego

Christine A. Sorkness · University of California, San Diego

Daniel J. Jackson · University of California, San Diego

Susan Boehmer · University of California, San Diego

Fernando D. Martínez · University of California, San Diego

Robert C. Strunk

Abstract

Nearly all the children had a differential response to each step-up therapy. LABA step-up was significantly more likely to provide the best response than either ICS or LTRA step-up. However, many children had a best response to ICS or LTRA step-up therapy, highlighting the need to regularly monitor and appropriately adjust each child's asthma therapy. (ClinicalTrials.gov number, NCT00395304.)

Topics & Keywords

Asthma and respiratory diseases Respiratory and Cough-Related Research Inhalation and Respiratory Drug Delivery

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 362, Issue 11, pp. 975-985

DOI: 10.1056/nejmoa1001278

Field-Weighted Citation Impact: 27.68