Circulating Irisin in Relation to Insulin Resistance and the Metabolic Syndrome

2013506 citationsJournal Articlebronze Open Access

Authors

Kyung‐Hee Park · Beth Israel Deaconess Medical Center

Lesya Zaichenko · Harvard University

Mary Brinkoetter · Beth Israel Deaconess Medical Center

Bindiya Thakkar · Harvard University

Ayse Sahin-Efe · VA Boston Healthcare System

Kyoung Eun Joung · Boston Children's Hospital

Michael A. Tsoukas

Abstract

Irisin is associated with increased risk of MetS, cardiometabolic variables, and CVD in humans, indicating either increased secretion by adipose/muscle tissue and/or a compensatory increase of irisin to overcome an underlying irisin resistance in these subjects.

Topics & Keywords

Adipose Tissue and Metabolism Adipokines, Inflammation, and Metabolic Diseases Fatty Acid Research and Health

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 98, Issue 12, pp. 4899-4907

DOI: 10.1210/jc.2013-2373

Field-Weighted Citation Impact: 24.94