Controlled Assembly of Vesicle‐Based Nanocontainers on Layer‐by‐Layer Particles via DNA Hybridization

200931 citationsJournal Article

Authors

Martin Loew

Jing Kang · Surflay Nanotec (Germany)

Lars Dähne · Surflay Nanotec (Germany)

Ruth Hendus‐Altenburger · Humboldt-Universität zu Berlin

Oliver Kaczmarek · Humboldt-Universität zu Berlin

Jürgen Liebscher · Humboldt-Universität zu Berlin

Daniel Huster · Leipzig University

Abstract

Microscopic colloidal particles allow a precise regulation of chemical reactions in time and place. A controlled assembly of multiple layers of intact lipid vesicles on a solid support provided by layer-by-layer particles functionalized by a covalent attachment of DNA oligonucleotides is reported (see image). Lipophilic complementary oligonucleotides are incorporated into lipid vesicles. Fusion of liposomes and release can be triggered.

Topics & Keywords

Advanced biosensing and bioanalysis techniques Lipid Membrane Structure and Behavior RNA Interference and Gene Delivery

Publication Details

Published in: Small

Volume 5, Issue 3, pp. 320-323

DOI: 10.1002/smll.200800989

Field-Weighted Citation Impact: 2.36

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Controlled Assembly of Vesicle‐Based Nanocontainers on Layer‐by‐Layer Particles via DNA Hybridization

Authors

Abstract

Topics & Keywords

Publication Details