Comparison of Pregabalin with Pramipexole for Restless Legs Syndrome

2014234 citationsJournal Article

Authors

Richard P. Allen · Johns Hopkins University

Crystal Chen · Pfizer (United States)

Diego García‐Borreguero · Sleep Research Society

Olli Polo · Tampere University

Sarah Dubrava · Pfizer (United States)

Jeffrey Miceli · Pfizer (United States)

Lloyd Knapp ·

Abstract

Pregabalin provided significantly improved treatment outcomes as compared with placebo, and augmentation rates were significantly lower with pregabalin than with 0.5 mg of pramipexole. (Funded by Pfizer; ClinicalTrials.gov number, NCT00806026.).

Topics & Keywords

Restless Legs Syndrome Research Parkinson's Disease Mechanisms and Treatments Sleep and Wakefulness Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 370, Issue 7, pp. 621-631

DOI: 10.1056/nejmoa1303646

Field-Weighted Citation Impact: 21.02