Mercaptopurine Therapy Intolerance and Heterozygosity at the Thiopurine S-Methyltransferase Gene Locus

1999731 citationsJournal Articlebronze Open Access

Authors

Mary V. Relling · St. Jude Children's Research Hospital

M L Hancock · University of Tennessee at Knoxville

Gaston K. Rivera · St. Jude Children's Research Hospital

John T. Sandlund · American Association of Colleges of Pharmacy

R. C. Ribeiro · American Association of Colleges of Pharmacy

Eugene Y. Krynetski · University of Tennessee at Knoxville

Ching‐Hon Pui

Abstract

We conclude that genetic polymorphism in TPMT is an important determinant of mercaptopurine toxicity, even among patients who are heterozygous for this trait.

Topics & Keywords

Acute Lymphoblastic Leukemia research Childhood Cancer Survivors' Quality of Life Adolescent and Pediatric Healthcare

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 91, Issue 23, pp. 2001-2008

DOI: 10.1093/jnci/91.23.2001

Field-Weighted Citation Impact: 22.53