Controlled Cell Adhesion on PEG‐Based Switchable Surfaces

2008361 citationsJournal Article

Authors

Erik Wischerhoff · Fraunhofer Institute for Applied Polymer Research

Katja Uhlig · Fraunhofer Institute for Biomedical Engineering

Andreas Lankenau · Fraunhofer Society

Hans G. Börner · Max Planck Institute of Colloids and Interfaces

André Laschewsky · University of Potsdam

Claus Duschl · Fraunhofer Society

Jean‐François Lutz

Abstract

A wash and brush up: Thermoresponsive and biocompatible oligo(ethylene glycol)-based copolymers enable the control of cell adhesion on planar gold substrates. While at physiological temperature, the polymer brushes are collapsed and enable fibroblast adhesion and cultivation, at room temperature, the now hydrated oligo(ethylene glycol) segments become cell-repellent, thus allowing cell harvesting under mild conditions (see scheme).

Topics & Keywords

Polymer Surface Interaction Studies Surface Modification and Superhydrophobicity

Publication Details

Published in: Angewandte Chemie International Edition

Volume 47, Issue 30, pp. 5666-5668

DOI: 10.1002/anie.200801202

Field-Weighted Citation Impact: 19.36

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Controlled Cell Adhesion on PEG‐Based Switchable Surfaces

Authors

Abstract

Topics & Keywords

Publication Details