Size dependent translocation and fetal accumulation of gold nanoparticles from maternal blood in the rat

2014148 citationsJournal Articlegold Open Access

Authors

Manuela Semmler‐Behnke · Helmholtz Zentrum München

Jens Lipka · Helmholtz Zentrum München

Alexander Wenk · Helmholtz Zentrum München

Stephanie Hirn · Helmholtz Zentrum München

Martin Schäffler · Helmholtz Zentrum München

Furong Tian · Helmholtz Zentrum München

Günter Schmid

Abstract

Our data suggest that the translocation of AuNP from maternal blood into the fetus is NP-size dependent which is due to mechanisms involving (1) transport through transtrophoblastic channels - also present in the human placenta - and/or (2) endocytotic and diffusive processes across the placental barrier.

Topics & Keywords

Pregnancy and preeclampsia studies Heavy Metal Exposure and Toxicity Trace Elements in Health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Particle and Fibre Toxicology

Volume 11, Issue 1, pp. 33-33

DOI: 10.1186/s12989-014-0033-9

Field-Weighted Citation Impact: 8.13