Time course and progression of wild type α-Synuclein accumulation in a transgenic mouse model

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Authors

David Amschl · QPS (Austria)

Joerg Neddens · QPS (Austria)

Daniel Havas · QPS (Austria)

Stefanie Flunkert · QPS (Austria)

Roland Rabl · QPS (Austria)

Heinrich Römer · University of Graz

Edward Rockenstein · University of California, San Diego

Abstract

The present study demonstrates that the PDGF-β α-Syn transgenic mouse model presents with early and progressive accumulation of human α-Syn that is accompanied by motor deficits. This information is essential for the design of therapeutical studies of synucleinopathies.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Neurological disorders and treatments Autism Spectrum Disorder Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Neuroscience

Volume 14, Issue 1, pp. 6-6

DOI: 10.1186/1471-2202-14-6

Field-Weighted Citation Impact: 1.23