Mechanical Ventilation–induced Diaphragm Disuse in Humans Triggers Autophagy

2010263 citationsJournal Articlegreen Open Access

Authors

Sabah N. A. Hussain · Christie (Canada)

Mahroo Mofarrahi · Christie (Canada)

Ioanna Sigala · National and Kapodistrian University of Athens

Ho Cheol Kim · Gyeongsang National University

Theodoros Vassilakopoulos · National and Kapodistrian University of Athens

François Maltais · Institut universitaire de cardiologie et de pneumologie de Québec

Ion Bellenis

Abstract

We propose that prolonged CMV causes diaphragm disuse, which, in turn, leads to activation of the ALP through oxidative stress and the induction of the FOXO1 transcription factor.

Topics & Keywords

Autophagy in Disease and Therapy Respiratory Support and Mechanisms Adipose Tissue and Metabolism

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 182, Issue 11, pp. 1377-1386

DOI: 10.1164/rccm.201002-0234oc

Field-Weighted Citation Impact: 14.04

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Mechanical Ventilation–induced Diaphragm Disuse in Humans Triggers Autophagy

Authors

Abstract

Topics & Keywords

Publication Details