Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure

2007188 citationsJournal Articlebronze Open Access

Authors

Jun Nakae · Kobe University

Yongheng Cao · Kobe University

Miyo Oki · Kobe University

Yasuko Orba · Hokkaido University

Hirofumi Sawa · Hokkaido University

Hiroshi Kiyonari · Genetic Resources Center

Kristy Iskandar · Kobe University

Abstract

These data suggest that FoxO1 modulates energy homeostasis in WAT and BAT through regulation of adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake.

Topics & Keywords

FOXO transcription factor regulation Adipose Tissue and Metabolism Sirtuins and Resveratrol in Medicine

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: Diabetes

Volume 57, Issue 3, pp. 563-576

DOI: 10.2337/db07-0698

Field-Weighted Citation Impact: 5.36