Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose

20081,469 citationsJournal Articlebronze Open Access

Authors

Christine H. Chung · Vanderbilt University

Beloo Mirakhur · Bristol-Myers Squibb (United States)

Emily Chan

Quynh‐Thu Le · Menlo School

Jordan Berlin

Michael A. Morse · Duke Medical Center

Barbara A. Murphy

Shama M. Satinover · University of Virginia

Abstract

In most subjects who had a hypersensitivity reaction to cetuximab, IgE antibodies against cetuximab were present in serum before therapy. The antibodies were specific for galactose-alpha-1,3-galactose.

Topics & Keywords

Drug-Induced Adverse Reactions Food Allergy and Anaphylaxis Research Monoclonal and Polyclonal Antibodies Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 358, Issue 11, pp. 1109-1117

DOI: 10.1056/nejmoa074943

Field-Weighted Citation Impact: 65.33