Impairment of Diastolic Function by Lack of Frequency-Dependent Myofilament Desensitizationin Rabbit Right Ventricular Hypertrophy

200938 citationsJournal Article

Authors

Kenneth D. Varian · QED Labs

Anusak Kijtawornrat · QED Labs

Subash Gupta · QED Labs

Carlos A. A. Torres · QED Labs

Michelle M. Monasky · The Ohio State University

Nitisha Hiranandani · QED Labs

Dawn A. Delfín · The Ohio State University

Abstract

The frequency-dependent myofilament desensitization is significantly impaired in right ventricular hypertrophy and contributes to the frequency-dependent elevation of diastolic tension in hypertrophy.

Topics & Keywords

Cardiac electrophysiology and arrhythmias Cardiovascular Effects of Exercise Cardiovascular Function and Risk Factors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Heart Failure

Volume 2, Issue 5, pp. 472-481

DOI: 10.1161/circheartfailure.109.853200

Field-Weighted Citation Impact: 2.97