Sensitivity and specificity of pooled versus individual sera in a human immunodeficiency virus antibody prevalence study

198983 citationsJournal Articlebronze Open Access

Authors

Barbara Cahoon-Young · Alameda County Public Health Department

Asa C. Chandler · Alameda County Public Health Department

Tim Livermore · Alameda County Public Health Department

James A. Gaudino · Alameda County Public Health Department

R Benjamin · Alameda County Public Health Department

Abstract

We evaluated the efficacy of testing pooled versus individual sera for the detection of human immunodeficiency virus antibody. A total of 5,000 individual specimens and 500 pools of 10 specimens each were assayed by an enzyme-linked immunosorbent assay. There was complete agreement in human immunodeficiency virus enzyme-linked immunosorbent assay reactivity for pooled versus individual specimens. An estimated savings of 60 to 80% (labor and supplies) can be realized dependent upon pooling and assay format.

Topics & Keywords

HIV Research and Treatment Blood groups and transfusion HIV/AIDS Research and Interventions

UN Sustainable Development Goals

Decent work and economic growth

Publication Details

Published in: Journal of Clinical Microbiology

Volume 27, Issue 8, pp. 1893-1895

DOI: 10.1128/jcm.27.8.1893-1895.1989

Field-Weighted Citation Impact: 0.24