Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma

2013113 citationsJournal Articlegold Open Access

Authors

Timothy R. Gershon · University of North Carolina at Chapel Hill

Andrew Crowther · University of North Carolina at Chapel Hill

Andrey P. Tikunov · University of North Carolina at Chapel Hill

Idoia García · University of North Carolina at Chapel Hill

Ryan P. Annis · University of North Carolina at Chapel Hill

Hong Yuan · University of North Carolina at Chapel Hill

C. Ryan Miller

Abstract

Our investigations demonstrate that aerobic glycolysis in cancer derives from developmental mechanisms that persist in tumorigenesis. Moreover, we demonstrate in a primary tumor model the anti-cancer potential of blocking aerobic glycolysis by targeting Hk2.See commentary article:http://www.biomedcentral.com/1741-7007/11/3.

Topics & Keywords

Cancer, Hypoxia, and Metabolism Epigenetics and DNA Methylation Glioma Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer & Metabolism

Volume 1, Issue 1, pp. 2-2

DOI: 10.1186/2049-3002-1-2

Field-Weighted Citation Impact: 4.43