A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele

20112,215 citationsJournal Articlebronze Open Access

Authors

N. Scott Adzick · Children's Hospital of Philadelphia

Elizabeth Thom · George Washington University

Catherine Y. Spong · National Institutes of Health

John W. Brock · Vanderbilt University

Pamela K. Burrows · George Washington University

Mark P. Johnson

Lori J. Howell

Jody A. Farrell

Abstract

Prenatal surgery for myelomeningocele reduced the need for shunting and improved motor outcomes at 30 months but was associated with maternal and fetal risks. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT00060606.).

Topics & Keywords

Spinal Dysraphism and Malformations Congenital Anomalies and Fetal Surgery Cerebrospinal fluid and hydrocephalus

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 364, Issue 11, pp. 993-1004

DOI: 10.1056/nejmoa1014379

Field-Weighted Citation Impact: 116.02