Accelerated Titration Designs for Phase I Clinical Trials in Oncology

1997637 citationsJournal Articlebronze Open Access

Authors

Richard Simon

Larry Rubinstein · National Cancer Institute

Susan G. Arbuck · National Cancer Institute

Michaele C. Christian · National Cancer Institute

Boris Freidlin · Emmes (United States)

Jerry M. Collins · United States Food and Drug Administration

Abstract

Accelerated titration (i.e., rapid intrapatient drug dose escalation) designs appear to effectively reduce the number of patients who are under-treated, speed the completion of phase I trials, and provide a substantial increase in the information obtained.

Topics & Keywords

Statistical Methods in Clinical Trials Optimal Experimental Design Methods Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 89, Issue 15, pp. 1138-1147

DOI: 10.1093/jnci/89.15.1138

Field-Weighted Citation Impact: 12.79