Highly Enantioselective Conjugate Addition of Nitromethane to Chalcones Using Bifunctional Cinchona Organocatalysts

2005976 citationsJournal Article

Authors

Benedek Vakulya · Hungarian Academy of Sciences

Szilárd Varga · Eötvös Loránd University

Antal Csámpai · Hungarian Academy of Sciences

Tibor Soós · Hungarian Academy of Sciences

Abstract

Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.

Topics & Keywords

Synthesis of heterocyclic compounds Asymmetric Synthesis and Catalysis Multicomponent Synthesis of Heterocycles

Publication Details

Published in: Organic Letters

Volume 7, Issue 10, pp. 1967-1969

DOI: 10.1021/ol050431s

Field-Weighted Citation Impact: 26.10

Command Palette

Highly Enantioselective Conjugate Addition of Nitromethane to Chalcones Using Bifunctional Cinchona Organocatalysts

Authors

Abstract

Topics & Keywords

Publication Details