Effects of Metformin Versus Glipizide on Cardiovascular Outcomes in Patients With Type 2 Diabetes and Coronary Artery Disease

2012355 citationsJournal Articlehybrid Open Access

Authors

Jie Hong · Shanghai Jiao Tong University

Yifei Zhang · Shanghai Jiao Tong University

Shenghan Lai · Johns Hopkins University

Ankang Lv · Shanghai Jiao Tong University

Qing Su · Shanghai Jiao Tong University

Dong Yan · Shanghai University of Traditional Chinese Medicine

Zhiguang Zhou

Abstract

Treatment with metformin for 3 years substantially reduced major cardiovascular events in a median follow-up of 5.0 years compared with glipizide. Our results indicated a potential benefit of metformin therapy on cardiovascular outcomes in high-risk patients.

Topics & Keywords

Diabetes Treatment and Management Diabetes, Cardiovascular Risks, and Lipoproteins Metabolism, Diabetes, and Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes Care

Volume 36, Issue 5, pp. 1304-1311

DOI: 10.2337/dc12-0719

Field-Weighted Citation Impact: 10.47