Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

2009487 citationsJournal Articlebronze Open Access

Authors

Dao‐Fu Dai · Maine Farmland Trust

Luis F. Santana · Maine Farmland Trust

Marc Vermulst · Maine Farmland Trust

Daniela M. Tomazela · Maine Farmland Trust

Mary J. Emond · Maine Farmland Trust

Michael J. MacCoss · Maine Farmland Trust

Katherine A. Gollahon ·

Abstract

This study shows that cardiac aging in the mouse closely recapitulates human aging and demonstrates the critical role of mitochondrial reactive oxygen species in cardiac aging and the impact of cardiac aging on survival. These findings also support the potential application of mitochondrial antioxidants in reactive oxygen species-related cardiovascular diseases.

Topics & Keywords

Cardiac Fibrosis and Remodeling Cardiovascular Function and Risk Factors Cardiac Ischemia and Reperfusion

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 119, Issue 21, pp. 2789-2797

DOI: 10.1161/circulationaha.108.822403

Field-Weighted Citation Impact: 16.90