Calcium-Channel Blocker–Clarithromycin Drug Interactions and Acute Kidney Injury

2013153 citationsJournal Article

Authors

Sonja Gandhi · Western University

Jamie L Fleet · Western University

David G. Bailey · Lawson Health Research Institute

Eric McArthur · Western University

Ron Wald · St. Michael's Hospital

Faisal Rehman · Western University

Amit X. Garg ·

Abstract

Among older adults taking a calcium-channel blocker, concurrent use of clarithromycin compared with azithromycin was associated with a small but statistically significant greater 30-day risk of hospitalization with acute kidney injury. These findings support current safety warnings regarding concurrent use of CYP3A4 inhibitors and calcium-channel blockers.

Topics & Keywords

Antibiotics Pharmacokinetics and Efficacy Pharmaceutical Practices and Patient Outcomes Pharmacovigilance and Adverse Drug Reactions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA

Volume 310, Issue 23, pp. 2544-2544

DOI: 10.1001/jama.2013.282426

Field-Weighted Citation Impact: 13.63