Diagnosis-Independent Alzheimer Disease Biomarker Signature in Cognitively Normal Elderly People

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Authors

Abstract

The mixture modeling approach, totally independent of clinical AD diagnosis, correctly classified patients with AD. The unexpected presence of the AD signature in more than one-third of cognitively normal subjects suggests that AD pathology is active and detectable earlier than has heretofore been envisioned.

Topics & Keywords

Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Schizophrenia research and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Archives of Neurology

Volume 67, Issue 8, pp. 949-949

DOI: 10.1001/archneurol.2010.179

Field-Weighted Citation Impact: 34.35