Bendamustine (Treanda) Displays a Distinct Pattern of Cytotoxicity and Unique Mechanistic Features Compared with Other Alkylating Agents

2008364 citationsJournal Article

Authors

Lorenzo M. Leoni

Brandi Bailey · San Diego State University

Jack Reifert · University of California, Santa Barbara

Heather Bendall · Neurocrine Biosciences (United States)

Robert W. Zeller · San Diego State University

Jacques Corbeil · Université Laval

Gary Elliott

Christina C. Niemeyer

Abstract

These results suggest that bendamustine possesses mechanistic features that differentiate it from other alkylating agents and may contribute to its distinct clinical efficacy profile.

Topics & Keywords

Acute Myeloid Leukemia Research Cancer therapeutics and mechanisms DNA Repair Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 14, Issue 1, pp. 309-317

DOI: 10.1158/1078-0432.ccr-07-1061

Field-Weighted Citation Impact: 13.87