Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque

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Authors

Esperanza Agulló-Pascual · New York University

Dylan A. Reid · New York University

Sarah Keegan · New York University

Manavjeet Sidhu · New York University

David Fenyö · New York University

Eli Rothenberg · New York University

Mario Delmar ·

Abstract

(i) Super-resolution fluorescence microscopy, complemented with Monte-Carlo simulations and PLAs, allows the study of the nanoscale organization of an interactome in cardiomyocytes. (ii) PKP2 and Cx43 share a common hub that permits direct physical interaction. Its relevance to excitability, electrical coupling, and arrhythmogenic right ventricular cardiomyopathy, is discussed.

Topics & Keywords

Cardiovascular Effects of Exercise Advanced Fluorescence Microscopy Techniques Cardiac electrophysiology and arrhythmias

Publication Details

Published in: Cardiovascular Research

Volume 100, Issue 2, pp. 231-240

DOI: 10.1093/cvr/cvt191

Field-Weighted Citation Impact: 4.85

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Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque

Authors

Abstract

Topics & Keywords

Publication Details