Hypophosphorylation of Aqueous Humor sCD44 and Primary Open-Angle Glaucoma

200541 citationsJournal Article

Authors

Paul A. Knepper · Northwestern University

Adam M. Miller · Memorial Medical Center

John Y. Choi · Memorial Medical Center

Robert D. Wertz · Northwestern University

Michael Nolan · University of Illinois Chicago

William Goossens · Memorial Medical Center

Susan Whitmer ·

Abstract

POAG aqueous is characterized by posttranslational change in the pI of sCD44 and hypophosphorylation, which clearly distinguished POAG from normal aqueous humor. The high toxicity and low HA-binding affinity of hypophosphorylated sCD44 may represent specific pathophysiologic features of the POAG disease process.

Topics & Keywords

Glaucoma and retinal disorders Proteoglycans and glycosaminoglycans research Retinal Diseases and Treatments

Publication Details

Published in: Investigative Ophthalmology & Visual Science

Volume 46, Issue 8, pp. 2829-2829

DOI: 10.1167/iovs.04-1472

Field-Weighted Citation Impact: 2.77

Command Palette

Hypophosphorylation of Aqueous Humor sCD44 and Primary Open-Angle Glaucoma

Authors

Abstract

Topics & Keywords

Publication Details