Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

2011558 citationsReviewgold Open Access

Authors

Tuomas O. Kilpeläinen · Medical Research Council

Lu Qi · Harvard University

Søren Brage · Medical Research Council

Stephen J. Sharp · Medical Research Council

Emily Sonestedt · Skåne University Hospital

Ellen W. Demerath · University of Minnesota

Tariq Ahmad ·

Abstract

The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.

Topics & Keywords

Obesity, Physical Activity, Diet Nutrition, Genetics, and Disease Nutritional Studies and Diet

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS Medicine

Volume 8, Issue 11, pp. e1001116-e1001116

DOI: 10.1371/journal.pmed.1001116

Field-Weighted Citation Impact: 49.92