Patches of Disorganization in the Neocortex of Children with Autism

2014737 citationsJournal Articlebronze Open Access

Authors

Rich Stoner · Autism Research Institute

Maggie Chow · Autism Research Institute

Maureen P. Boyle · University of California, San Diego

Susan M. Sunkin · Allen Institute for Brain Science

Peter R. Mouton · University of South Florida

Subhojit Roy · University of California, San Diego

Anthony Wynshaw‐Boris

Abstract

In this small, explorative study, we found focal disruption of cortical laminar architecture in the cortexes of a majority of young children with autism. Our data support a probable dysregulation of layer formation and layer-specific neuronal differentiation at prenatal developmental stages. (Funded by the Simons Foundation and others.).

Topics & Keywords

Autism Spectrum Disorder Research Genetics and Neurodevelopmental Disorders Williams Syndrome Research

Publication Details

Published in: New England Journal of Medicine

Volume 370, Issue 13, pp. 1209-1219

DOI: 10.1056/nejmoa1307491

Field-Weighted Citation Impact: 43.20

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Patches of Disorganization in the Neocortex of Children with Autism

Authors

Abstract

Topics & Keywords

Publication Details