β-Blockers Restore Calcium Release Channel Function and Improve Cardiac Muscle Performance in Human Heart Failure

2003300 citationsJournal Article

Authors

Steven Reiken · Advanced Circulatory System (United States)

Xander H.T. Wehrens · Advanced Circulatory System (United States)

Joshua R. Vest · Advanced Circulatory System (United States)

Alessandro Barbone · Advanced Circulatory System (United States)

Stefan Klotz · Advanced Circulatory System (United States)

Donna Mancini · Advanced Circulatory System (United States)

Daniel Burkhoff

Abstract

Improved cardiac muscle function during beta-AR blockade is associated with improved cardiac Ca2+ release channel function in patients with heart failure.

Topics & Keywords

Cardiac electrophysiology and arrhythmias Ion channel regulation and function Heart Failure Treatment and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 107, Issue 19, pp. 2459-2466

DOI: 10.1161/01.cir.0000068316.53218.49

Field-Weighted Citation Impact: 14.66