Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

2010598 citationsJournal Articlebronze Open Access

Authors

John M. Wentworth · Monash University

Gaetano Naselli · Walter and Eliza Hall Institute of Medical Research

Wendy A. Brown · Monash University

Lisa Doyle · Monash University

Belinda Phipson · Walter and Eliza Hall Institute of Medical Research

Gordon K. Smyth · Walter and Eliza Hall Institute of Medical Research

Martin Wabitsch

Abstract

These findings identify proinflammatory CD11c(+) ATMs as markers of insulin resistance in human obesity. In addition, the machinery of CD11c(+) ATMs indicates they metabolize lipid and may initiate adaptive immune responses.

Topics & Keywords

Adipokines, Inflammation, and Metabolic Diseases Immune cells in cancer Adipose Tissue and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes

Volume 59, Issue 7, pp. 1648-1656

DOI: 10.2337/db09-0287

Field-Weighted Citation Impact: 20.28