Comparative sensitivity of HBV NATs and HBsAg assays for detection of acute HBV infection

2003259 citationsJournal Article

Authors

Robin Biswas · San Francisco General Hospital

Edward Tabor · Alpha Medical (Slovakia)

Chu Chieh Hsia · National Heart Lung and Blood Institute

David J. Wright · Center for Biologics Evaluation and Research

Megan E. Laycock · Vitalant

Eberhard Fiebig · National Heart Lung and Blood Institute

Lorraine Peddada

Abstract

Newer HBsAg tests would be expected to detect an additional 15 to 21 infected units per 107 donations, compared to licensed HBsAg tests. Sensitivity, WP closure, and yield projections for newer HBsAg assays and pooled-sample NAT are comparable. Single-sample NAT would increase yield by 13 to 15 units per 107 donations over pooled-sample NAT and newer HBsAg assays and by 35 to 50 units per 107 donations over currently licensed HBsAg assays.

Topics & Keywords

Hepatitis B Virus Studies Viral Infections and Outbreaks Research Hepatitis C virus research

Publication Details

Published in: Transfusion

Volume 43, Issue 6, pp. 788-798

DOI: 10.1046/j.1537-2995.2003.00424.x

Field-Weighted Citation Impact: 12.31

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Comparative sensitivity of HBV NATs and HBsAg assays for detection of acute HBV infection

Authors

Abstract

Topics & Keywords

Publication Details