Structural Heterogeneity Alone Is a Sufficient Substrate for Dynamic Instability and Altered Restitution

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Authors

Zoar J. Engelman · University of Auckland

Bruce H. Smaill · University of Auckland

Abstract

We show that structural discontinuities can amplify discordant alternans and provide a rate-dependent substrate for reentry. This work provides new insights into the mechanisms by which fibrosis may contribute to arrhythmogenesis.

Topics & Keywords

Cardiac electrophysiology and arrhythmias Cardiac pacing and defibrillation studies Ion channel regulation and function

Publication Details

Published in: Circulation Arrhythmia and Electrophysiology

Volume 3, Issue 2, pp. 195-203

DOI: 10.1161/circep.109.890459

Field-Weighted Citation Impact: 2.67

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Structural Heterogeneity Alone Is a Sufficient Substrate for Dynamic Instability and Altered Restitution

Authors

Abstract

Topics & Keywords

Publication Details