Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival

20091,109 citationsJournal Articlebronze Open Access

Authors

Mari M. Kitahata · Harborview Medical Center

Stephen J. Gange · Harborview Medical Center

Alison G. Abraham · Harborview Medical Center

Barry Merriman · Harborview Medical Center

Michael S Saag · University of Alabama at Birmingham

Amy C. Justice · Harborview Medical Center

Robert S. Hogg

Abstract

The early initiation of antiretroviral therapy before the CD4+ count fell below two prespecified thresholds significantly improved survival, as compared with deferred therapy.

Topics & Keywords

HIV/AIDS Research and Interventions HIV/AIDS drug development and treatment HIV Research and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 360, Issue 18, pp. 1815-1826

DOI: 10.1056/nejmoa0807252

Field-Weighted Citation Impact: 77.10