The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

20121,136 citationsReviewhybrid Open Access

Authors

Daniel I. Swerdlow · University College London

Michael V Holmes · University College London

Karoline B Kuchenbaecker · University of Cambridge

Jorgen E L Engmann · University College London

Tina Shah · University College London

Reecha Sofat · University College London

Yiran Guo

Christina Chung · University College London

Abstract

UK Medical Research Council; British Heart Foundation; Rosetrees Trust; US National Heart, Lung, and Blood Institute; Du Pont Pharma; Chest, Heart and Stroke Scotland; Wellcome Trust; Coronary Thrombosis Trust; Northwick Park Institute for Medical Research; UCLH/UCL Comprehensive Medical Research Centre; US National Institute on Aging; Academy of Finland; Netherlands Organisation for Health Research and Development; SANCO; Dutch Ministry of Public Health, Welfare and Sports; World Cancer Research Fund; Agentschap NL; European Commission; Swedish Heart-Lung Foundation; Swedish Research Council; Strategic Cardiovascular Programme of the Karolinska Institutet; Stockholm County Council; US National Institute of Neurological Disorders and Stroke; MedStar Health Research Institute; GlaxoSmithKline; Dutch Kidney Foundation; US National Institutes of Health; Netherlands Interuniversity Cardiology Institute of the Netherlands; Diabetes UK; European Union Seventh Framework Programme; National Institute for Healthy Ageing; Cancer Research UK; MacArthur Foundation.

Topics & Keywords

Cytokine Signaling Pathways and Interactions Viral Infections and Immunology Research NF-κB Signaling Pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Lancet

Volume 379, Issue 9822, pp. 1214-1224

DOI: 10.1016/s0140-6736(12)60110-x

Field-Weighted Citation Impact: 32.70