Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE

2013928 citationsJournal Article

Authors

Nasim Mavaddat

Susan Peock

Abstract

Prospective risk estimates confirm that BRCA1 and BRCA2 carriers are at high risk of developing breast, ovarian, and contralateral breast cancer. Our results confirm findings from retrospective studies that common breast cancer susceptibility alleles in combination are predictive of breast cancer risk for BRCA2 carriers.

Topics & Keywords

BRCA gene mutations in cancer Cancer Genomics and Diagnostics Genomic variations and chromosomal abnormalities

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 105, Issue 11, pp. 812-822

DOI: 10.1093/jnci/djt095

Field-Weighted Citation Impact: 52.64