Epithelial Cell Mitochondrial Dysfunction and PINK1 Are Induced by Transforming Growth Factor- Beta1 in Pulmonary Fibrosis

2015178 citationsJournal Articlegold Open Access

Authors

Avignat S. Patel · Harvard University

Jin Woo Song · Ulsan College

Sarah Chu · Brigham and Women's Hospital

Kenji Mizumura · Cornell University

Juan C. Osorio · Brigham and Women's Hospital

Ying Shi · Brigham and Women's Hospital

Souheil El‐Chemaly ·

Abstract

TGF-β1 induces lung epithelial cell mitochondrial ROS and depolarization and stabilizes the key mitophagy initiating protein, PINK1. PINK1 ameliorates epithelial cell death and may be necessary to limit fibrogenesis.

Topics & Keywords

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Autophagy in Disease and Therapy Transplantation: Methods and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 10, Issue 3, pp. e0121246-e0121246

DOI: 10.1371/journal.pone.0121246

Field-Weighted Citation Impact: 13.15