PspC, a Pneumococcal Surface Protein, Binds Human Factor H

2001214 citationsJournal Articlegreen Open Access

Authors

Sandhya Dave · Czech Academy of Sciences, Institute of Microbiology

Alexis Brooks-Walter · University of Alabama at Birmingham

Michael K. Pangburn · The University of Texas Health Science Center at Tyler

Larry S. McDaniel · Czech Academy of Sciences, Institute of Microbiology

Abstract

PspC was found to bind human complement factor H (FH) by Western blot analysis of D39 (pspC(+)) and an isogenic mutant TRE108 (pspC). We confirmed that PspA does not bind FH, while purified PspC binds FH very strongly. The binding of FH to exponentially growing pneumococci varied among different isolates when analyzed by fluorescence activated cell sorting analysis.

Topics & Keywords

Neonatal and Maternal Infections Pneumonia and Respiratory Infections Bacterial Infections and Vaccines

Publication Details

Published in: Infection and Immunity

Volume 69, Issue 5, pp. 3435-3437

DOI: 10.1128/iai.69.5.3435-3437.2001

Field-Weighted Citation Impact: 11.73

Command Palette

PspC, a Pneumococcal Surface Protein, Binds Human Factor H

Authors

Abstract

Topics & Keywords

Publication Details