Lactate Dehydrogenase B: A Metabolic Marker of Response to Neoadjuvant Chemotherapy in Breast Cancer

2013116 citationsJournal Articlebronze Open Access

Authors

Jennifer B. Dennison · Vanderbilt University

Jennifer R. Molina · Vanderbilt University

Shreya Mitra · Breast Cancer Care

Ana M. González-Angulo · The University of Texas Health Science Center at Houston

Justin M. Balko · Vanderbilt University

María G. Kuba · The University of Texas Health Science Center at Houston

Melinda E. Sanders

Abstract

Expression of LDHB predicted response to neoadjuvant chemotherapy within clinical subtypes independently of standard prognostic markers and PAM50 subtyping. These observations support prospective clinical evaluation of LDHB as a predictive marker of response for patients with breast cancer receiving neoadjuvant chemotherapy.

Topics & Keywords

Breast Cancer Treatment Studies Cancer, Hypoxia, and Metabolism Cancer Cells and Metastasis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 19, Issue 13, pp. 3703-3713

DOI: 10.1158/1078-0432.ccr-13-0623

Field-Weighted Citation Impact: 4.43