An International Ki67 Reproducibility Study

2013592 citationsJournal Articlebronze Open Access

Authors

Mei‐Yin C. Polley · National Institutes of Health

Samuel Leung · University of British Columbia

Lisa M. McShane · National Institutes of Health

Dongxia Gao · University of British Columbia

Judith Hugh · University of Alberta

Mauro G. Mastropasqua · Istituti di Ricovero e Cura a Carattere Scientifico

Giuseppe Viale

Abstract

Substantial variability in Ki67 scoring was observed among some of the world's most experienced laboratories. Ki67 values and cutoffs for clinical decision-making cannot be transferred between laboratories without standardizing scoring methodology because analytical validity is limited.

Topics & Keywords

Breast Cancer Treatment Studies Cancer Genomics and Diagnostics Gene expression and cancer classification

UN Sustainable Development Goals

Peace, Justice and strong institutions

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 105, Issue 24, pp. 1897-1906

DOI: 10.1093/jnci/djt306

Field-Weighted Citation Impact: 20.59