Impaired myocardial perfusion reserve and fibrosis in Friedreich ataxia: a mitochondrial cardiomyopathy with metabolic syndrome

201081 citationsJournal Articlebronze Open Access

Authors

Subha V. Raman · The Ohio State University

K. Phatak · The Ohio State University

J.C. HOYLE · The Ohio State University

Michael L. Pennell · The Ohio State University

Beth McCarthy · The Ohio State University

Tam Tran · The Ohio State University

Thomas W. Prior ·

Abstract

Patients with FA have abnormal myocardial perfusion reserve that parallels met-S severity. Impaired perfusion reserve and fibrosis occur in the absence of significant hypertrophy and prior to clinical heart failure, providing potential therapeutic targets for stage B cardiomyopathy in FA and related myocardial diseases.

Topics & Keywords

Genetic Neurodegenerative Diseases Mitochondrial Function and Pathology Advanced MRI Techniques and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: European Heart Journal

Volume 32, Issue 5, pp. 561-567

DOI: 10.1093/eurheartj/ehq443

Field-Weighted Citation Impact: 1.95