Protective role of 1,25(OH)2vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice

2012268 citationsJournal Articlegold Open Access

Authors

Hongwei Zhao · Hebei Medical University

Hong Zhang · Second Hospital of Hebei Medical University

Hui Wu · Hebei Medical University

Hui Li · Second Hospital of Hebei Medical University

Lei Liu · Second Hospital of Hebei Medical University

Jian Guo · Hebei Medical University

Chenyang Li

Abstract

1,25(OH)2D3 may play a protective role in mucosal barrier homeostasis by maintaining the integrity of junction complexes and in healing capacity of the colon epithelium. 1,25(OH)2D3 may represent an attractive and novel therapeutic agent for the adjuvant therapy of IBD.

Topics & Keywords

Vitamin D Research Studies Gut microbiota and health Microscopic Colitis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Gastroenterology

Volume 12, Issue 1, pp. 57-57

DOI: 10.1186/1471-230x-12-57

Field-Weighted Citation Impact: 10.08