Cellular Aging Reflected by Leukocyte Telomere Length Predicts Advanced Atherosclerosis and Cardiovascular Disease Risk

2010286 citationsJournal Article

Authors

Peter Willeit · Innsbruck Medical University

Johann Willeit · Krankenhaus Bruneck

Anita Kloss‐Brandstätter · University of Cambridge

Silvia Ehrlenbach · University of Cambridge

Agnes Mayr · Krankenhaus Bruneck

Arno Gasperi · University of Cambridge

Siegfried Weger ·

Abstract

Our findings indicate a differential role of telomere shortening in the various stages of atherosclerosis, with preferential involvement in advanced vessel pathology and acute vascular syndromes.

Topics & Keywords

Telomeres, Telomerase, and Senescence Neutrophil, Myeloperoxidase and Oxidative Mechanisms Genetics, Aging, and Longevity in Model Organisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 30, Issue 8, pp. 1649-1656

DOI: 10.1161/atvbaha.110.205492

Field-Weighted Citation Impact: 8.70