Gonadoblastoma Arising in Undifferentiated Gonadal Tissue within Dysgenetic Gonads

2006226 citationsJournal Articlegreen Open Access

Authors

Martine Cools · Meertens Institute

Hans Stoop · Meertens Institute

Anne‐Marie F. Kersemaekers · Meertens Institute

Stenvert L. S. Drop

Katja P. Wolffenbuttel · Erasmus University Rotterdam

Jean-Pierre Bourguignon · University of Liège

Jolanta Słowikowska‐Hilczer · Medical University of Lodz

Abstract

Based on these observations, we hypothesize that gonadoblastomas originate from surviving OCT3/4-positive germ cells in areas of undifferentiated gonadal tissue within the dysgenetic gonad. Supportive evidence was obtained that carcinoma in situ arises in regions with testicular differentiation.

Topics & Keywords

Testicular diseases and treatments Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities Sexual Differentiation and Disorders

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 91, Issue 6, pp. 2404-2413

DOI: 10.1210/jc.2005-2554

Field-Weighted Citation Impact: 12.78

Command Palette

Gonadoblastoma Arising in Undifferentiated Gonadal Tissue within Dysgenetic Gonads

Authors

Abstract

Topics & Keywords

Publication Details